In:
European Journal of Haematology, Wiley, Vol. 75, No. 5 ( 2005-11), p. 370-375
Abstract:
Abstract: Objectives : Purpose of this study was to compare prognostic factors and outcome of patients with multiple myeloma (MM) aged 〉 70 yr at diagnosis with those of younger patients. We also applied the recently proposed International Staging System (ISS) for MM in these patients. Patients and methods : Among 1,162 newly diagnosed, symptomatic MM patients included in our database, 357 (31%) were 〉 70 yr of age. Clinical and laboratory variables were evaluated in patients 〉 70 yr and in younger patients and were assessed for possible correlation with survival in patients 〉 70 yr of age. Results : Most clinical and laboratory features were similar in the two groups of patients but older patients presented more frequently with advanced ISS ( P = 0.02). Despite similar response rates to primary treatment, younger patients survived longer than patients 〉 70 yr of age (40 vs. 28 months, P = 0.001). There was a longer survival of younger patients than that of older patients diagnosed with ISS stage 1 (median 71 vs. 54 months, P = 0.007) and ISS stage‐2 patients (median: 38 vs. 26 months, P = 0.0008) but for patients with ISS stage 3 median survival was similarly poor in the younger and older age group (21 and 20 months, P = 0.283). Other variables associated with impaired prognosis were severe anemia, extensive bone marrow plasmacytosis and elevated serum LDH. Conclusions : Older patients with MM present more often with advanced ISS and have significantly shorter survival than younger patients. The ISS retained its prognostic significance within the group of elderly patients.
Type of Medium:
Online Resource
ISSN:
0902-4441
,
1600-0609
DOI:
10.1111/ejh.2005.75.issue-5
DOI:
10.1111/j.1600-0609.2005.00532.x
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2027114-1
detail.hit.zdb_id:
392482-8
