In:
Clinical and Experimental Pharmacology and Physiology, Wiley, Vol. 23, No. 6-7 ( 1996-07), p. 472-475
Abstract:
1. In the present study the possible relationship between adrenomedullin (AM) and calcitonin gene‐related peptide (CGRP) in the regulation of airway functions in anaesthetized guinea‐pigs was examined in vivo . 2. We found that AM significantly inhibited histamine‐induced bronchoconstriction in a dose‐dependent manner. CGRP or the CGRP receptor antagonist (CGRP [8–37]) alone did not affect pulmonary resistance and pretreatment with CGRP or CGRP [8–37] did not significantly affect histamine‐induced bronchoconstriction. However, AM‐induced broncho‐protection was significantly inhibited by pretreatment with CGRP or CGRP [8–37] in a dose‐dependent manner. 3. It is therefore possible that CGRP may be competitive, at least in part, with binding sites of AM in the guinea‐pig airway. Exogenous AM may be useful for the management of bronchial asthma, not only as a potent bronchodilator, but also as a functional antagonist of CGRP.
Type of Medium:
Online Resource
ISSN:
0305-1870
,
1440-1681
DOI:
10.1111/cep.1996.23.issue-6-7
DOI:
10.1111/j.1440-1681.1996.tb02763.x
Language:
English
Publisher:
Wiley
Publication Date:
1996
detail.hit.zdb_id:
189277-0
detail.hit.zdb_id:
2020033-X
SSG:
15,3