In:
Clinical Genetics, Wiley, Vol. 17, No. 2 ( 1980-02), p. 108-114
Abstract:
Chromosome studies were performed on peripheral blood lymphocytes of 28 patients with connective tissue disease (6 with progressive systemic sclerosis, 6 with systemic lupus erythematosus, 6 with anti‐nuclear antibody positive rheumatoid arthritis, 6 with anti‐nuclear antibody negative rheumatoid arthritis, and 4 with mixed connective tissue disease) and on 17 controls to determine the frequency of spontaneous as well as X‐ray (75 rads) induced aberrations. The mean spontaneous chromosomal aberration frequency for the 28 patients (9.1 %) was significantly ( P = 0.038) greater than that of controls (6.4 %). When patients were categorized into specific clinically designated connective tissue disease subdivisions for comparison with the controls, only X‐irradiated cells from the progressive systemic sclerosis group displayed significantly elevated levels of total chromosomal aberrations over those of the control group. The X‐irradiated lymphocytes from these patients had an average of 23.6 % aberrations per patient, while those of the control group showed an average of 14.9 % per patient ( P 〈 0.05).
Type of Medium:
Online Resource
ISSN:
0009-9163
,
1399-0004
DOI:
10.1111/cge.1980.17.issue-2
DOI:
10.1111/j.1399-0004.1980.tb00116.x
Language:
English
Publisher:
Wiley
Publication Date:
1980
detail.hit.zdb_id:
2004581-5
detail.hit.zdb_id:
221209-2
