In:
Parasite Immunology, Wiley, Vol. 32, No. 11-12 ( 2010-11), p. 760-763
Abstract:
Filarial nematodes down‐regulate the host immune response to establish infection by inducing IL‐10‐mediated T‐cell suppression. Abundant larval transcript (ALT) proteins are of major interest as they are expressed abundantly in the L3 stage, implicated in protective immunity and may play a role in immune evasion. The T‐cell epitopes of BmALT‐2 and the cytokine responses induced by these peptides were investigated in a mouse model using synthetic peptides, which could be exploited in the design of a potent epitope‐based vaccine. Five regions were found to carry T‐cell epitopes inducing high levels of cellular proliferation. The regions 55–68 and 73–91 of ALT‐2 induced very high levels of IL‐10 secretion and hence could be involved in immunomodulation in the host.
Type of Medium:
Online Resource
ISSN:
0141-9838
,
1365-3024
DOI:
10.1111/pim.2010.32.issue-11-12
DOI:
10.1111/j.1365-3024.2010.01239.x
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
2020808-X
SSG:
12