In:
International Journal of Dermatology, Wiley, Vol. 53, No. 12 ( 2014-12)
Abstract:
CD 4+ CD 25+ T‐regulatory ( T reg) cells play critical roles in maintaining peripheral tolerance and preventing autoimmunity. As characteristics of Treg cells have not been precisely investigated in chronic urticaria ( CU ) yet, this study was performed. Objective To determine the frequencies of circulating CD 4+ CD 25+ FOXP 3+ T cells and serum levels of interleukin ( IL )‐10, transforming growth factor ( TGF )‐ β , and IL ‐17 in patients with chronic autoimmune urticaria and chronic idiopathic urticaria compared to healthy controls. Methods Peripheral blood mononuclear cells ( PBMC s) were obtained from patients with CU and healthy controls. The frequency of CD 4+ CD 25+ T cells in PBMC s and expression levels of FOXP 3 were detected by flow cytometry. The serum levels of IL ‐10, TGF ‐ β , and IL ‐17 were measured by enzyme‐linked immunosorbent assay. Results A significant decrease in the percentage of circulating CD 4+ CD 25+ FOXP 3+ T cells was detected in patients with CU , compared to control subjects. However, no significant difference was detected on the serum levels of IL ‐10, TGF ‐ β , and IL ‐17 between patients with CU and control subjects. Conclusions This study demonstrated that the frequency of T reg cells in PBMC s was decreased in patients with CU . Further studies are needed to clarify the exact role of T reg cells in the pathogenesis of CU and factors regulating their function.
Type of Medium:
Online Resource
ISSN:
0011-9059
,
1365-4632
DOI:
10.1111/ijd.2014.53.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2020365-2
