In:
Diabetes, Obesity and Metabolism, Wiley, Vol. 23, No. 8 ( 2021-08), p. 1834-1842
Abstract:
To investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG) and glucagon‐like peptide‐1 (GLP‐1) secretion, and to compare responses with those elicited by isocaloric glucose (GLU) administration. Methods We examined 10 healthy young men on three separate occasions using a placebo (PBO)‐controlled crossover design. A KE versus taste‐matched isovolumetric and isocaloric 50% GLU and taste‐matched isovolumetric PBO vehicle was orally administered. Our main outcome measures were plasma concentrations of AG, UAG, glucose‐dependent insulinotropic polypeptide (GIP) and GLP‐1 along with appetite sensation scores assessed by visual analogue scale. Results KE ingestion resulted in an average peak beta‐hydroxybutyrate concentration of 5.5 mM. AG and UAG were lowered by approximately 25% following both KE and GLU intake compared with PBO. In the case of AG, the differences were −52.1 (−79.4, –24.8) for KE and −48.4 (−75.4, −21.5) pg/mL for GLU intake ( P 〈 .01). Concentrations of AG remained lower with KE but returned to baseline and were comparable with PBO levels after GLU intake. GLP‐1, GIP, gastrin and cholecystokinin were not affected by KE ingestion. Conclusion Our results suggest that the suppressive effects on appetite sensation scores associated with hyperketonaemia are more probable to be mediated through reduced ghrelin concentrations than by increased activity of cholecystokinin, gastrin, GIP or GLP‐1.
Type of Medium:
Online Resource
ISSN:
1462-8902
,
1463-1326
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2004918-3
