In:
Contact Dermatitis, Wiley, Vol. 71, No. 3 ( 2014-09), p. 170-175
Abstract:
Drug patch tests ( DPT s) with medicaments suspected of causing an allergic reaction represent a method of diagnostic testing that is low risk; DPT s can reproduce delayed hypersensitivity to drugs, and entail only a moderate re‐exposure of patients to potential offending drugs. We assessed the non‐irritating concentrations of DPT s and determined the amounts of active ingredient ( AI ) contained in the drugs used in the tests. Objectives The objectives were to assess the non‐irritating concentration of DPTs and determine the amounts of active ingredient (AI) contained in the drugs used in the tests. Methods From a retrospective, single‐centre study of all patients investigated during a 6‐year period with a drug eruption, each potentially responsible drug was tested with the commercially available preparation diluted to 30% in water, petrolatum, or alcohol. Data collection was performed with a customized computer database. For each type of DPT studied, the numbers of positive and negative test results were recorded. The amount of AI contained in the DPT (as a percentage) was then calculated after weighing of each tablet. Results Of the 5558 DPT s studied, all were non‐irritant. The average concentration of AI was 9.8%; 25% of DPT s had an AI concentration of 〈 2%, and 25% had an AI concentration of 〉 16%. The AI concentration ranged from 0.05% (digoxin) to 30% (paracetamol lyophilisate). Conclusion These data provide thresholds for the non‐irritating concentration of AI of 68 different drugs, and thresholds for the non‐irritating dilution for 82 drugs, and will help to standardize DPT methods.
Type of Medium:
Online Resource
ISSN:
0105-1873
,
1600-0536
DOI:
10.1111/cod.2014.71.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2027120-7
detail.hit.zdb_id:
193121-0
