In:
Clinical Endocrinology, Wiley, Vol. 88, No. 1 ( 2018-01), p. 88-95
Abstract:
Sex hormone trajectories in ageing men and their health implications remain unclear. We examined longitudinal trajectories and associations of testosterone (T), dihydrotestosterone ( DHT ), oestradiol (E2), luteinizing hormone ( LH ) and sex hormone‐binding globulin ( SHBG ) in oldest old men. Design Prospective cohort study. Participants We studied 1025 community‐dwelling men median age 75.1 years at baseline with 8.6 years of follow‐up. Measurements Baseline and follow‐up T, DHT and E2 were assayed using mass spectrometry. Physical performance was assessed at follow‐up. Correlations and covariate‐adjusted P ‐values were determined. Results Longitudinal change in T was −2.0%/year, DHT −7.2%/year, LH +7.5%/year, SHBG +5.6%/year while E2 remained stable. Annualized increases in LH correlated with decreases in T and DHT ( r = −.20, P 〈 .0001 and r = −.12, P = .0035, respectively). Higher baseline T correlated with better physical performance at follow‐up (eg, Step test r = .07, P = .03), as did higher baseline DHT (eg, time to sit–stand [ TSS ] r = −.07, P = .01). Larger annualized increases in LH predicted poorer physical performance at follow‐up (eg, TSS r = .14, P = .001). Higher T at follow‐up was associated with better physical performance (eg, TSS r = −.07, P = .04), as were higher DHT and lower LH . At baseline, 24 men (2.4%) had abnormally high LH ( 〉 16 IU/L); at follow‐up, 175 (17.4%) had high LH of whom 70 had low T ( 〈 6.4 nmol/L). Conclusions Annualized increases in LH are associated with declines in T and DHT , and predict poorer subsequent physical performance in oldest old men. Men transitioning from 8th to 9th decades exhibit biochemical evidence of progressively impaired testicular endocrine function, warranting further evaluation.
Type of Medium:
Online Resource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2018.88.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2004597-9
