In:
Chemical Biology & Drug Design, Wiley, Vol. 86, No. 6 ( 2015-12), p. 1373-1377
Abstract:
The antimalarial activity of peroxides most likely originates from their interaction with iron( II ) species located inside the malaria parasite, which forms destructive radical species through a Fenton‐like mechanism. This article reports the first evaluation of the in vitro antimalarial activity of three peroxides of the class 1,2‐dioxetanes against Plasmodium falciparum ; the results reveal that the studied 3‐methoxy‐1,2‐dioxetanes display significant antimalarial activity, at a similar level as artemisinin and also that their reactivity toward iron( II ) correlate linearly with their antimalarial activity.
Type of Medium:
Online Resource
ISSN:
1747-0277
,
1747-0285
DOI:
10.1111/cbdd.2015.86.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2216600-2
SSG:
12