In:
Cancer Science, Wiley, Vol. 107, No. 11 ( 2016-11), p. 1687-1695
Abstract:
Follicular lymphoma ( FL ) shows co‐expression of B‐cell lymphoma 2 ( BCL 2) and CD 10, whereas downexpression of CD 10 is occasionally experienced in gastrointestinal ( GI ) FL with unknown significance. Gastrointestinal FL is a rare variant of FL , and its similarity with mucosa‐associated lymphoid tissue lymphoma was reported. We investigated the clinicopathological and genetic features of CD 10 downexpressed ( CD 10 down ) GI ‐ FL . The diagnosis of CD 10 down FL was carried out with a combination of pathological and molecular analyses. The incidence of CD 10 down GI ‐ FL was shown in 35/172 (20.3%) cases, which was more frequent than nodal FL (3.5%, P 〈 0.001). The difference was additionally significant between GI ‐ FL and nodal FL when the analysis was confined to primary GI ‐ FL (55.2% vs 3.5%, P 〈 0.001). Compared to CD 10 + GI ‐ FL , CD 10 down GI ‐ FL significantly involved the stomach or large intestine ( P = 0.015), and additionally showed the downexpression of BCL 6 ( P 〈 0.001). The follicular dendritic cell meshwork often showed a duodenal pattern in the CD 10 down group ( P = 0.12). Furthermore, a lymphoepithelial lesion was observed in 5/12 (40%) gastric FL cases, which indicated caution in the differentiation of mucosa‐associated lymphoid tissue lymphoma. Molecular analyses were undertaken in seven cases of CD 10 down GI ‐ FL , and an identical clone was found between CD 10 down follicles and CD 10 + BCL 2 + neoplastic follicles. In the diagnosis of cases with CD 10 down BCL 2 + follicles, careful examination with molecular studies should be carried out.
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2016.107.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6