In:
Aging Cell, Wiley, Vol. 23, No. 6 ( 2024-06)
Abstract:
Aging is intricately linked to immune system dysfunction. Recent studies have highlighted the biological function of microRNA‐7 (miR‐7) as a novel regulator of immune cell function and related diseases. However, the potential role of miR‐7 in aging remains unexplored. Here, we investigated the contribution of miR‐7 to d ‐gal‐induced aging in mice, focusing on its regulation of senescent Kupffer cells. Our findings revealed that miR‐7 deficiency significantly ameliorated the aging process, characterized by enhanced CD4 + T‐cell activation. However, the adoptive transfer of miR‐7‐deficient CD4 + T cells failed to improve the age‐related phenotype. Further analysis showed that miR‐7 deficiency significantly reduced IL‐1β production in liver tissue, and inhibiting IL‐1β in vivo slowed down the aging process in mice. Notably, IL‐1β is mainly produced by senescent Kupffer cells in the liver tissue of aging mice, and miR‐7 expression was significantly up‐regulated in these cells. Mechanistically, KLF4, a target of miR‐7, was down‐regulated in senescent Kupffer cells in aging mouse model. Furthermore, miR‐7 deficiency also modulated the NF‐κB activation and IL‐1β production in senescent Kupffer cells through KLF4. In conclusion, our findings unveil the role of miR‐7 in d ‐gal‐induced aging in mice, highlighting its regulation of KLF4/NF‐κB/IL‐1β pathways in senescent Kupffer cells. This research may enhance our understanding of miRNA‐based aging immune cells and offer new avenues for new intervention strategies in aging process.
Type of Medium:
Online Resource
ISSN:
1474-9718
,
1474-9726
Language:
English
Publisher:
Wiley
Publication Date:
2024
detail.hit.zdb_id:
2113083-8
detail.hit.zdb_id:
2099130-7
SSG:
12
