In:
Microbiology, Microbiology Society, Vol. 155, No. 6 ( 2009-06-01), p. 1934-1939
Abstract:
Bacteria commonly communicate with each other by a cell-to-cell signalling mechanism known as quorum sensing (QS). Recent studies have shown that the Las QS autoinducer N -(3-oxododecanoyl)- l -homoserine lactone (3-oxo-C 12 -HSL) of Pseudomonas aeruginosa performs a variety of functions not only in intraspecies communication, but also in interspecies and interkingdom interactions. In this study, we report the effects of Pseudomonas 3-oxo-C 12 -HSL on the growth and suppression of virulence factors in other bacterial species that frequently co-exist with Ps. aeruginosa in nature. It was found that 3-oxo-C 12 -HSL, but not its analogues, suppressed the growth of Legionella pneumophila in a dose-dependent manner. However, 3-oxo-C 12 -HSL did not exhibit a growth-suppressive effect on Serratia marcescens , Proteus mirabilis , Escherichia coli , Alcaligenes faecalis and Stenotrophomonas maltophilia . A concentration of 50 μM 3-oxo-C 12 -HSL completely inhibited the growth of L. pneumophila . Additionally, a significant suppression of biofilm formation was demonstrated in L. pneumophila exposed to 3-oxo-C 12 -HSL. Our results suggest that the Pseudomonas QS autoinducer 3-oxo-C 12 -HSL exerts both bacteriostatic and virulence factor-suppressive activities on L. pneumophila alone.
Type of Medium:
Online Resource
ISSN:
1350-0872
,
1465-2080
DOI:
10.1099/mic.0.026641-0
Language:
English
Publisher:
Microbiology Society
Publication Date:
2009
detail.hit.zdb_id:
2008736-6
detail.hit.zdb_id:
1180712-X
SSG:
12
