In:
European Journal of Gastroenterology & Hepatology, Ovid Technologies (Wolters Kluwer Health), Vol. 33, No. 9 ( 2021-09), p. 1209-1217
Abstract:
The impact of viral eradication on hepatic angiogenesis is unknown. This study aimed to analyze the correlations of liver angiogenesis with liver fibrosis progression or regression in chronic hepatitis C (CHC) after viral eradication. Methods From 2003 to 2020, a cohort of 130 eligible participants underwent paired percutaneous liver biopsies (median = 48 months apart; range = 46–62) at the treatment baseline and after sustained virological response to CHC treatment at the tertiary referral center. The collagen proportionate area (CPA) of liver tissue sections was determined using picrosirius red staining through digital image analysis. CD34 and α-smooth muscle actin (α-SMA) phenotypically quantitated liver angiogenesis and myofibroblasts, respectively, through immunohistochemistry staining, to correlate the total, portal, and extraportal liver angiogenesis with fibrogenesis. Results Paired histology manifested significant regressions in fibrosis stages, and necroinflammatory grades (both P 〈 0.001). The median of changes in CPAs (follow-up minus baseline) was −6.12% (interquartile range = −12.35 to −2.05%). The median of CPA changes per year was −1.38%/year (interquartile range = −2.98 to −0.51%/year). The significance of declines in total CD34 [coefficient (95% confidence interval), 5.577 (3.286–7.868); P 〈 0.001] outweighed α-SMA declines, when explaining ( R 2 = 0.522; adjusted R 2 = 0.502) the CPA declines through multiple regression analysis adjusting for other histological variables. Conclusion Through viral eradication in CHC, the downregulated liver angiogenesis significantly explains the CPA regression.
Type of Medium:
Online Resource
ISSN:
0954-691X
DOI:
10.1097/MEG.0000000000001833
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
2030291-5
