In:
Cornea, Ovid Technologies (Wolters Kluwer Health), Vol. 37, No. 6 ( 2018-06), p. 673-677
Abstract:
To evaluate endothelial cell density (ECD) in the first 6 months after Descemet membrane endothelial keratoplasty (DMEK) by eliminating method error as a confounding variable. Methods: From 24 DMEK eyes operated for Fuchs endothelial corneal dystrophy, from which specular microscopy images could be taken at 1 day and 6 months postoperatively, ECD values were compared between these 2 time points. Results: Using the 1-day ECD measurement as baseline, mean ECD decreased from 1913 (±326) cells/mm 2 to 1524 (±393) cells/mm 2 at 6 months, a decline of −18 (±19)%. With the 1-week ECD as baseline [1658 (±395) cells/mm 2 ], the decline at 6 months was −6 (±19)% and when using preoperative ECD as baseline [2521 (±122) cells/mm 2 ], the decline was −39 (±16)% at 6 months. Conclusions: After DMEK, ECD shows an in vivo decline of 18% from 1 day to 6 months postoperatively, with a sharp 13% drop in the first week, and a slower decrease thereafter. The remaining difference of 20% from preoperative ECD values may be attributed to a measurement error in the eye bank with an overestimation of the graft's viable endothelial cell population and/or intraoperative trauma to the graft.
Type of Medium:
Online Resource
ISSN:
0277-3740
DOI:
10.1097/ICO.0000000000001484
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2018
detail.hit.zdb_id:
2045943-9
