In:
Cardiology Plus, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 2 ( 2023-04), p. 126-133
Abstract:
Associations between fine and coarse particulate matters (i.e., PM 2.5 and PM 2.5–10 , respectively) and the onset of angina have rarely been investigated. We aimed to systematically explore the impacts of PM 2.5 as well as PM 2.5–10 on the onset of stable and unstable angina at the hourly timescale. Methods: We performed a time-stratified case-crossover study among 995,734 angina patients from 1,655 hospitals in 305 Chinese cities from January 2015 to December 2021. Concentrations of PM 2.5 and PM 2.5–10 were collected at the hourly timescale from nearby fixed-site monitoring stations. Hourly onset information of unstable and stable angina was obtained from the Chinese Cardiovascular Association Database-Chest Pain Center. We applied conditional logistic regressions combined with polynomial distributed lag models to explore the lagged exposure–response associations. Subgroup analyses were performed to explore potential effect modifiers including age, sex, season, and region. Results: Transient exposure to PM 2.5 was significantly associated with elevated risk of unstable and stable angina onset. The associations occurred immediately in the concurrent hour of exposure, attenuated thereafter, and turned to null at approximately lag 12 h for unstable angina and 9 h for stable angina. Each interquartile range increase in the PM 2.5 concentrations over 0 to 12 h was associated with 1.32% (95% confidence interval [95% CI]: 0.94%–1.70%) and 1.69% (95% CI: 0.99%–2.39%) increase in the onset risk of unstable and stable angina, respectively. The results remained similar after controlling for co-pollutants. Greater magnitudes of associations were found among females and during cold season. Null associations were observed between PM 2.5–10 and any type of angina. Conclusion: Our study indicates that acute exposure to PM 2.5 , rather than PM 2.5–10 , was significantly associated with the onset of both unstable and stable angina, underscoring the need of continued efforts in controlling particulate matter air pollution.
Type of Medium:
Online Resource
ISSN:
2470-7511
DOI:
10.1097/CP9.0000000000000052
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2023
detail.hit.zdb_id:
2987027-6
