In:
Open Forum Infectious Diseases, Oxford University Press (OUP)
Abstract:
Respiratory syncytial virus (RSV) can cause severe disease among infants and older adults. Less is known about RSV among pregnant women. Methods We used data from women aged 18–49 years hospitalized with laboratory-confirmed RSV from the RSV Hospitalization Surveillance Network (RSV-NET), a multi-state population-based surveillance system, to compare characteristics and outcomes between: 1) pregnant and non-pregnant women during pre-COVID-19 pandemic (2014–2018) periods, 2) pregnant women with respiratory symptoms during pre-pandemic and pandemic periods (2021–2023), and 3) pregnant women with and without respiratory symptoms in the pandemic period. Using multivariable logistic regression, we examined whether pregnancy was a risk factor for severe outcomes (ICU admission or in-hospital death) among women aged 18–49 years hospitalized with RSV pre-pandemic. Results Pre-pandemic, 387 women 18–49 years were hospitalized with RSV. Of those, 350 (90.4%) had respiratory symptoms, among whom 33 (9.4%) were pregnant. Five (15.2%) pregnant women and 74 (23.3%) non-pregnant women were admitted to the ICU; no pregnant and 5 (1.6%) non-pregnant women died. Among 279 hospitalized pregnant women, 41 were identified pre-pandemic and 238 during the pandemic, 80.5% and 35.3% had respiratory symptoms, respectively (p & lt; 0.001). Pregnant women were more likely to deliver during their RSV-associated hospitalization during the pandemic compared to the pre-pandemic period (74.2% vs. 43.9%; p & lt; 0.001). Conclusion Few pregnant women had severe RSV disease, and pregnancy was not a risk factor for a severe outcome. More asymptomatic pregnant women were identified during the pandemic, likely due to changes in testing practices for RSV.
Type of Medium:
Online Resource
ISSN:
2328-8957
DOI:
10.1093/ofid/ofae042
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2024
detail.hit.zdb_id:
2757767-3
