In:
Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 35, No. Supplement_3 ( 2020-06-01)
Abstract:
Lupus nephritis (LN) is one of the major complications of systemic lupus erythematosus. Early intervention in lupus nephritis is known to benefit patients' prognosis. Recent studies have found an association between hyperuricemia and lupus nephritis, but the sex-specific role of uric acid in lupus nephritis remains unclear. The purpose of this study is to elucidate the relationship between lupus nephritis and hyperuricemia, and to investigate sex differences. Method We retrospectively analyzed 394 patients who diagnosed with LN by renal biopsy. We assessed the effect of serum uric acid on progression of LN using Kaplan–Meier survival analyses and Cox proportional hazards models. The study’s primary end point was LN progression that was defined as the initiation of dialysis. Results The male had a higher mean of serum uric acid level than female. In the overall patient analysis, every 1 mg / dL increase in baseline uric acid level increased the risk of LN progression by about 16.9%. The serum uric acid level was an independent risk factor for LN progression in female (hazard ratio [HR], 1.177; confidence interval [CI] ,1.024 to 1.353; P & lt;0.001) but not in male (HR, 1.0351; CI, 0.661 to 1.622; P = 0.880). A sensitivity analysis involving serum uric acid tertile generated consistent and robust results. Conclusion The serum uric acid level was an independent risk factor for LN progression in female but no in male.
Type of Medium:
Online Resource
ISSN:
0931-0509
,
1460-2385
DOI:
10.1093/ndt/gfaa142.P0378
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2020
detail.hit.zdb_id:
1465709-0
