In:
Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 75, No. 11 ( 2022-11-30), p. 1930-1939
Abstract:
Recent population-based data are limited regarding influenza-associated hospitalizations in US children. Methods We identified children & lt;18 years hospitalized with laboratory-confirmed influenza during 2010–2019 seasons, through the Centers for Disease Control and Prevention’s Influenza Hospitalization Surveillance Network. Adjusted hospitalization and in-hospital mortality rates were calculated, and multivariable logistic regression was conducted to evaluate risk factors for pneumonia, intensive care unit (ICU) admission, mechanical ventilation, and death. Results Over 9 seasons, adjusted influenza-associated hospitalization incidence rates ranged from 10 to 375 per 100 000 persons each season and were highest among infants & lt;6 months old. Rates decreased with increasing age. The highest in-hospital mortality rates were observed in children & lt;6 months old (0.73 per 100 000 persons). Over time, antiviral treatment significantly increased, from 56% to 85% (P & lt; .001), and influenza vaccination rates increased from 33% to 44% (P = .003). Among the 13 235 hospitalized children, 2676 (20%) were admitted to the ICU, 2262 (17%) had pneumonia, 690 (5%) required mechanical ventilation, and 72 (0.5%) died during hospitalization. Compared with those & lt;6 months of age, hospitalized children ≥13 years old had higher odds of pneumonia (adjusted odds ratio, 2.7 [95% confidence interval, 2.1–3.4], ICU admission (1.6 [1.3–1.9] ), mechanical ventilation (1.6 [1.1–2.2]), and death (3.3 [1.2–9.3] ). Conclusions Hospitalization and death rates were greatest in younger children at the population level. Among hospitalized children, however, older children had a higher risk of severe outcomes. Continued efforts to prevent and attenuate influenza in children are needed.
Type of Medium:
Online Resource
ISSN:
1058-4838
,
1537-6591
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2022
detail.hit.zdb_id:
1099781-7
detail.hit.zdb_id:
2002229-3
