In:
International Journal of Sports Medicine, Georg Thieme Verlag KG, Vol. 41, No. 03 ( 2020-03), p. 141-153
Abstract:
This study analyzed the effects of physical exercise interventions on
cardiovascular endpoints in childhood cancer survivors. Relevant articles were systematically searched in PubMed, CINAHL, and Web of Science databases
(since inception to 11th September 2019). We performed a meta-analysis (random effects) to determine the mean difference (expressed together with
95% confidence intervals) between pre- and post-intervention values for those cardiovascular endpoints reported in more than three studies.
Twenty-seven studies (of which 16 were controlled studies) comprising 697 participants were included. Only three studies reported adverse events
related to exercise interventions. Exercise resulted in an increased performance on the 6-minute walk distance test (mean
difference=111 m, 95% confidence interval=39–183, p=0.003) and a non-significant
trend (mean difference=1.97 ml∙kg−1∙min−1,
95% confidence interval=−0.12–4.06, p=0.065) for improvement in peak oxygen uptake. Furthermore, left
ventricular ejection fraction was preserved after exercise interventions (mean difference=0.29%, 95% confidence
interval=−1.41–1.99, p=0.738). In summary, exercise interventions might exert a cardioprotective effect in childhood
cancer survivors by improving – or attenuating the decline of – physical capacity and cardiovascular function. Further studies,
particularly randomized controlled trials, are needed to confirm these benefits.
Type of Medium:
Online Resource
ISSN:
0172-4622
,
1439-3964
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2020
detail.hit.zdb_id:
2041541-2
SSG:
31
