In:
Immunology, Wiley, Vol. 91, No. 1 ( 1997-05), p. 45-52
Abstract:
The roles of the inflammatory cytokines tumour necrosis factor‐ α (TNF‐ α ), interleukin‐1 (IL‐1) and IL‐12, in murine cytomegalovirus (MCMV) disease were investigated in susceptible BALB/c and resistant C57BL/6 mice. MCMV infection induced IL‐1 and TNF‐ α production by peritoneal cells from BALB/c mice, as demonstrated previously in C57BL/6 mice. Overt ill‐health and viral replication in the spleens of BALB/c mice were increased by in vivo treatment with soluble TNF‐ α receptors to inhibit the activity of this cytokine, whilst antibodies to IL‐12 had a similar but more restricted effect. C57BL/6 mice were not affected by either treatment, suggesting TNF‐ α and IL‐12 are not critical for natural killer cell‐mediated restriction of viral replication in the spleen. Soluble TNF‐ α receptors and antibodies to IL‐12 also enhanced MCMV titres and numbers of viral antigen‐positive cells in the livers of BALB/c mice and TNF‐ α receptors have similar effects in C57BL/6 livers. In contrast, IL‐1 receptors improved the health of MCMV‐infected BALB/c mice and reduced viral replication and hepatitis at some time‐points. Mechanisms which may underlie these changes are discussed.
Type of Medium:
Online Resource
ISSN:
0019-2805
,
1365-2567
DOI:
10.1046/j.1365-2567.1997.00226.x
Language:
English
Publisher:
Wiley
Publication Date:
1997
detail.hit.zdb_id:
2006481-0
