In:
British Journal of Haematology, Wiley, Vol. 103, No. 1 ( 1998-10), p. 213-216
Abstract:
Down syndrome (DS) children have a 10–20‐fold increased risk of developing ALL or AML compared to non‐DS children. An increased disomic homozygosity of the polymorphic DNA markers in the pericentromeric region of chromosome 21q (21q11) has repeatedly been found in DS patients with ANLL‐M7 and DS‐specific transient abnormal myelopoiesis (TAM), compared to the majority of DS subjects without leukaemia. Analysis of cytogenetic heteromorphisms and 26 polymorphic DNA markers from chromosome 21q showed an increased number of pericentromeric crossovers between the non‐disjoined chromosomes in DS‐ANLL cases (3/11), compared to DS‐ALL (0/9) and DS‐non‐leukaemic cases (0/12). These findings are compatible with the model of disomic homozygosity of the predisposing allele of a putative pericentromeric gene, as an explanation for the high prevalence of ANLL in DS.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1046/j.1365-2141.1998.00924.x
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
80077-6
detail.hit.zdb_id:
1475751-5