In:
British Journal of Haematology, Wiley, Vol. 100, No. 1 ( 1998-01), p. 219-221
Abstract:
Eight adult patients with bipolar disorder were prospectively examined to find whether lithium carbonate increased their peripheral blood CD34 + haemopoietic stem cells. Following lithium therapy for 3–4 weeks their neutrophil counts increased by a mean of 88% (from 4625 ± 1350 × 10 9 /l, mean ± SD pretreatment, to a peak of 8300 ± 3910 × 10 9 /l). Concommitantly, there was a significant increment in their CD34 + cells (from 0.11 ± 0.01% to a peak of 0.18 ± 0.08%). There was a significant correlation between the rise in neutrophil count and that of the CD34 + cells ( r = 0.795, P = 0.019). Lithium therapy may be used to mobilize peripheral blood CD34 + cells for marrow transplantation.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1046/j.1365-2141.1998.00537.x
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
80077-6
detail.hit.zdb_id:
1475751-5
