In:
Chemical Communications, Royal Society of Chemistry (RSC), Vol. 59, No. 46 ( 2023), p. 7092-7095
Abstract:
A unified strategy for accessing the core structure of cyathane diterpenoids has been developed, enabling the formal synthesis of (–)-erinacine B. The key feature includes an organocatalyzed asymmetric intramolecular vinylogous aldol reaction for convergently building up the 5-6-6 tricyclic ring system. This strategy also highlights a hydroxyl-directed cyclopropanation/ring opening sequence to stereoselectively set up 1,4- anti and - cis angular-methyl quaternary carbon centers.
Type of Medium:
Online Resource
ISSN:
1359-7345
,
1364-548X
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2023
detail.hit.zdb_id:
1472881-3