In:
New Journal of Chemistry, Royal Society of Chemistry (RSC), Vol. 46, No. 31 ( 2022), p. 15219-15226
Kurzfassung:
A binuclear Schiff base copper( ii ) complex [Cu 2 (L-H) 2 ]Cl 2 (1, L = N -(2-hydroxylbenzylidene)-benzo[ d ]imidazol-2-amine) was synthesized and characterized by elemental analysis, ESI-MS, HRMS, IR, and molar conductivity. Magnetization measurements revealed that 1 showed the usual, moderate-to-strong intramolecular antiferromagnetically coupling exchange interaction between two copper( ii ) centers. The electrochemical behaviour in DMF showed that 1 has followed quasi-irreversible nature with two successive one-electron reductions as follows: Cu II Cu II ⇔ Cu II Cu I ⇔ Cu I Cu I . Complex 1 could bind to DNA by the groove binding mode and electrostatic interaction and induce a conformational variation in DNA. Additionally, 1 could efficiently cleave the supercoiled plasmid DNA into its nicked and linear forms by the oxidative mechanism. The cell experiments showed that 1 could effectively enter cancer cells, even the nucleus, induce cellular apoptosis, and exhibit cytotoxicity comparable to that of cisplatin against HeLa and A549 cell lines; it also has a more potent cytotoxicity against MCF-7 cell lines.
Materialart:
Online-Ressource
ISSN:
1144-0546
,
1369-9261
Sprache:
Englisch
Verlag:
Royal Society of Chemistry (RSC)
Publikationsdatum:
2022
ZDB Id:
1472933-7
