In:
Biomaterials Science, Royal Society of Chemistry (RSC), Vol. 10, No. 12 ( 2022), p. 3137-3157
Abstract:
The treatment of sepsis caused by bacterial infections is still a huge clinical challenge. As sepsis causes high levels of endogenous H 2 S in vivo , researchers can design nanomedicines to treat sepsis by in situ sulfurization. Here, we designed and synthesized Cu 2 O-coated non-metallic core–shell selenium nanoparticles. To cure mice sepsis by ROS burst. Our experimental data displayed that the photothermal effect of Se@Cu 9 S 8 produced by the reaction of Se@Cu 2 O and endogenous H 2 S is synergistically antibacterial, and Se@Cu 2 O has the characteristics of low side effects and high biocompatibility. In summary, our research results verified our design, that copper–selenium nanoclusters may be an efficient strategy to cure sepsis by in situ sulfurization of endogenous H 2 S, triggering ROS eruptions and photothermal therapy.
Type of Medium:
Online Resource
ISSN:
2047-4830
,
2047-4849
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
2693928-9