In:
Organic Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 9, No. 7 ( 2022), p. 1932-1936
Abstract:
A highly enantioselective conjugate addition of indolizine and its analogues with α,β-unsaturated 2-acyl imidazoles has been developed. In the presence of 1.0 mol% of Δ-Rh1, the corresponding adducts were obtained in good yields (85–98%) with excellent enantioselectivities (95%– 〉 99%) to resolve the difficult issue faced with organocatalysts which could not control well the stereoselectivity of the reaction due to monofunctional activation. Remarkably, this protocol exhibits extraordinary advantages in terms of reactivity and enantioselectivity, given the fact that as low as 0.05 mol% of Δ-Rh1 can promote the title reaction on gram scale to afford the desired product with excellent enantioselectivity.
Type of Medium:
Online Resource
ISSN:
2052-4129
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
2757215-8
