In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-03-29)
Abstract:
Stress and recovery from stress significantly affect interactions between the central nervous system, endocrine pathways and the immune system. However, the influence of acute stress on circulating immune-endocrine mediators in humans is not well known. Using a double-blind, randomized study design, we administered a CO 2 stress test to n = 143 participants to identify the effects of acute stress and recovery from stress, on serum levels of several mediators with immune function (IL-6, TNF-α, leptin and somatostatin), as well as on noradrenaline and two hypothalamic–pituitary–adrenal axis hormones (ACTH and cortisol). Moreover, during a 1 h-recovery period, we repeatedly measured these serum parameters and administered an auditory mood-induction protocol with positive music and a neutral control stimulus. The acute stress elicited increases in noradrenaline, ACTH, cortisol, IL-6 and leptin levels. Noradrenaline and ACTH exhibited the fastest and strongest stress responses, followed by cortisol, IL-6 and leptin. The music intervention was associated with more positive mood and stronger cortisol responses to the acute stressor in the music group. Our data show that acute (CO 2 ) stress affects endocrine, immune and metabolic functions in humans and they show that mood plays a causal role in the modulation of responses to acute stress.
Type of Medium:
Online Resource
ISSN:
2045-2322
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2016
detail.hit.zdb_id:
2615211-3
