In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-09-15)
Abstract:
Previous studies have investigated the association between osteopontin ( OPN ) gene polymorphisms, rs17524488 ( −156 GG/G ), rs11730582 ( −443 T/C ) and rs9138 ( C/A ) and cancer risk in the Chinese population. However, the results are controversial and indefinite. We therefore carried out a meta-analysis to derive a more precise estimation of these associations. The PubMed database was systematically searched to identify potentially eligible reports. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations between 3 OPN gene polymorphisms and cancer risk in a Chinese population. A total of 10 articles involving 2,391 cases and 3,007 controls were evaluated. The pooled OR indicated that OPN rs17524488 ( −156 GG/G ) polymorphism was significantly associated with cancer risk in Chinese population. In a stratified analysis by source of control, significant associations were also observed among rs17524488 (−156 GG/G ) and rs11730582 ( −443 T/C ) polymorphisms and cancer. In addition, a stronger association was observed between rs9138 ( C/A ) polymorphism and cancer risk. In conclusion, this meta-analysis suggests that OPN rs17524488 ( −156 GG/G ), rs11730582 ( −443 T/C ) and rs9138 ( C/A ) polymorphisms may be associated with cancer susceptibility in the Chinese population. Nevertheless, further investigation on a larger population covering different ethnicities are warranted.
Type of Medium:
Online Resource
ISSN:
2045-2322
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2015
detail.hit.zdb_id:
2615211-3
