In:
Immunology & Cell Biology, Wiley, Vol. 85, No. 5 ( 2007-07), p. 394-396
Abstract:
T‐cell receptor (TCR) transgenic mice have proven useful for the study of various immune parameters. Despite this, it has been suggested that transferred T cells respond differently to their endogenous counterparts at least in terms of conversion to antigen‐experienced populations bearing memory cell markers. Here, we have compared the response of TCR transgenic T cells to endogenous populations within the context of infection with herpes simplex virus. We found that adoptive transfer at numbers approaching those of the endogenous virus‐specific subset results in a response with similar kinetics, magnitude and memory subset conversion. This suggests that this form of optimized T‐cell transfer remains a useful means of tracking antiviral immune responses.
Type of Medium:
Online Resource
ISSN:
0818-9641
,
1440-1711
DOI:
10.1038/sj.icb.7100076
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2011707-3
SSG:
12