In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-11-22)
Kurzfassung:
Two crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick ( Rhipicephalus appendiculatus ), have been determined at 2.2 and 2.4 Å resolution. In both crystal forms the protein is in complex with cholesterol, which sits in a closed pocket at the centre of the lipocalin barrel. Both crystal forms are dimers, which are also observed in solution. Molecular modelling suggests that previously-described members of a tick protein family bearing high sequence homology to Japanin are also likely to bind cholesterol or cholesterol derivatives.
Materialart:
Online-Ressource
ISSN:
2045-2322
DOI:
10.1038/s41598-017-16413-2
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2017
ZDB Id:
2615211-3