In:
npj Systems Biology and Applications, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2018-08-02)
Abstract:
Complex organisms originate from and are maintained by the information encoded in the genome. A major challenge of systems biology is to develop algorithms that describe the dynamic regulation of genome functions from large omics datasets. Here, we describe TETRAMER, which reconstructs gene-regulatory networks from temporal transcriptome data during cell fate transitions to predict “master” regulators by simulating cascades of temporal transcription-regulatory events.
Type of Medium:
Online Resource
ISSN:
2056-7189
DOI:
10.1038/s41540-018-0066-z
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2018
detail.hit.zdb_id:
2841868-2