In:
npj Schizophrenia, Springer Science and Business Media LLC, Vol. 1, No. 1 ( 2015-10-28)
Abstract:
This work addresses the existing and emerging evidence of overlap within the environmental and genetic profiles of multiple sclerosis (MS) and schizophrenia. Aims: To investigate whether a genetic risk factor for MS (rs703842), whose variation is indicative of vitamin D status in the disorder, could also be a determinant of vitamin D status in chronic psychosis patients. Methods: A cohort of 224 chronic psychosis cases was phenotyped and biologically profiled. The relationship between rs703842 and physiological vitamin D status in the blood plasma was assessed by logistic regression. Deficiency was defined as a blood plasma concentration below 10 ng/µl. Potential environmental confounders of the vitamin D status were considered as part of the analysis. Results: We report suggestive evidence of an association with vitamin D status in established psychosis ( ß standardized =0.51, P =0.04). The logistic model fit significantly benefited from controlling for body mass index, depression and ethnicity ( χ 2 =91.7; 2 degrees of freedom (df); P =1.2×10 20 ). Conclusions: The results suggest that, in addition to lifestyle changes that accompany the onset of illness, vitamin D dysregulation in psychosis has a genetic component that links into MS. Further, comprehensive studies are needed to evaluate this prospect.
Type of Medium:
Online Resource
ISSN:
2334-265X
DOI:
10.1038/npjschz.2015.36
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2015
detail.hit.zdb_id:
2813844-2
detail.hit.zdb_id:
3133210-9
