In:
Quarterly Reviews of Biophysics, Cambridge University Press (CUP), Vol. 32, No. 1 ( 1999-02), p. 1-56
Abstract:
Nucleoside triphosphates are crucial mediators of life. The high energy phosphoanhydride
bond of (usually) ATP is used to drive unfavorable chemical reactions, to fuel biological machines, and to regulate a vast number of processes via phosphorylation of proteins. GTP,
in turn, is used almost exclusively for the regulation of signal transduction and transport processes, whereas the other nucleotides play a less important role, except in synthesis
pathways involving sugars (UTP) and phospholipids (CTP) and as building blocks of polynucleotides such as RNA and DNA. Proteins that bind and use these nucleotides for
enzymatic reaction and regulation are very diverse. Although some of them constitute the largest protein superfamilies known (e.g. protein kinases), others seem to be far less
conserved in evolution.
Type of Medium:
Online Resource
ISSN:
0033-5835
,
1469-8994
DOI:
10.1017/S0033583599003480
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
1999
detail.hit.zdb_id:
1474559-8
SSG:
12
