In:
The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 34, No. 10 ( 2018-10), p. 539-546
Abstract:
Diabetic wound care is a major health care concern. The major cause of non‐healing of wounds in patients with diabetes mellitus (DM) patients mainly involves poor glycemic control, which hinders the migration of progenitor cells including mesenchymal stem cells to the wound site. In this study, we introduced adipose‐derived stromal cells (ADSCs) into wound sites and demonstrated that the local transplantation of ADSCs accelerated DM‐related wound healing. Furthermore, the migration ability of ADSCs, which diminishes in a high‐glucose environment, was partially restored by the exogenous replenishment of the cutaneous T‐cell attracting chemokine (CTACK/CCL27). Our findings suggest that CTACK is a potential novel therapeutic target in DM‐related wound healing.
Type of Medium:
Online Resource
ISSN:
1607-551X
,
2410-8650
DOI:
10.1016/j.kjms.2018.05.002
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2202782-8
detail.hit.zdb_id:
2248033-X