In:
Journal of Arrhythmia, Wiley, Vol. 29, No. 3 ( 2013-06), p. 168-174
Abstract:
The purpose of this study was to clarify the prognosis of cardiac resynchronization therapy with defibrillators (CRT‐Ds) in Japan. Methods We selected 384 patients implanted with a CRT‐D device from the observation database ( n =1482) of the Japanese Cardiac Device Therapy Registry. We investigated the CRT criteria, including the presence of New York Heart Association (NYHA) class III/IV symptoms, left ventricular ejection fraction (LVEF) ≤35%, and QRS duration ≥120 ms. The patients were divided into 2 groups: the group fulfilling all of the 3 criteria (Group A, n =229) and the group not fulfilling the criteria (Group B, n =155). We compared mortality and appropriate shock rates between the 2 groups. Results There was no significant difference in mortality (17.9% vs. 13.5%) or appropriate shock rates (32.5% vs. 31.6%) during the observation period of 29.0±15.7 months between the 2 groups. A logistic multivariate analysis showed that appropriate shocks (hazard ratio [HR]=1.85) and class III antiarrhythmic agents (HR=2.33) were independently associated with all‐cause death, and that age ≥70 years (HR=0.55), male gender (HR=2.07), and presence of a single‐chamber device (HR=1.78) were associated with appropriate shocks. The prognosis of Group A was better than that of the COMPANION trial. Conclusions Japanese patients with CRT‐D devices had a better prognosis than did those in the COMPANION trial, but no significant differences were observed between patients fulfilling and those not fulfilling the above mentioned criteria.
Type of Medium:
Online Resource
ISSN:
1880-4276
,
1883-2148
DOI:
10.1016/j.joa.2013.04.006
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2696593-8
