In:
Alzheimer's & Dementia, Wiley, Vol. 15, No. 10 ( 2019-10), p. 1333-1347
Abstract:
We detected three gene categories operating differently in AD subgroups of patients. Vasculature regulation may be an essential part of the causative mechanism in pure AD. Two novel signals reached genome‐wide significance in ANKRD31 and NDUFAF6 loci. We confirmed SCIMP‐rs7225151 and CD33‐rs3865444 to be genome‐wide significant. Genetic discoveries are strongly impacted by the presence of subgroups of AD.
Type of Medium:
Online Resource
ISSN:
1552-5260
,
1552-5279
DOI:
10.1016/j.jalz.2019.06.4950
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2201940-6