In:
Cell Biology International, Wiley, Vol. 33, No. 1 ( 2009-01), p. 31-35
Abstract:
Restricted numbers and poor regenerative properties limit the use of adult stem cells. We tested the effect of hypoxic treatment as a method by which to increase cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations of 0.1, 3, and 20% for 24 h. After hypoxic treatment, BMCs of apoptotic fraction were decreased. The expression of CXCR4 was noticeably increased in the hypoxia‐treated BMCs and their migration in response to SDF‐1α was enhanced compared with cells cultured under normoxic condition. Hypoxic BMCs had a higher degree of engraftment to the CCl 4 ‐injured liver than the normoxic cells. Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells as well as in enhancing cellular migration to SDF‐1α, the chemokine which binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl 4 damaged liver.
Type of Medium:
Online Resource
ISSN:
1065-6995
,
1095-8355
DOI:
10.1016/j.cellbi.2008.10.002
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
1462519-2
detail.hit.zdb_id:
1143453-3
SSG:
12