In:
FEBS Letters, Wiley, Vol. 524, No. 1-3 ( 2002-07-31), p. 123-126
Abstract:
Aldosterone is thought to regulate cardiac work independently of sodium retention, though the mechanisms remain to be known. In the present study, we have demonstrated that aldosterone reinforces endothelin‐mediated cardiac hypertrophy with the increase in cell surface area and upregulation of the transcripts characteristic of hypertrophy. We have also shown that aldosterone augments c‐Jun N‐terminal kinase activation induced by endothelin‐1. Taken together, it is suggested that aldosterone modulates cardiac hypertrophy, at least partially, synergistically with extracellular signals that have been shown to be involved in cardiac remodeling.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(02)03017-X
Language:
English
Publisher:
Wiley
Publication Date:
2002
detail.hit.zdb_id:
212746-5
detail.hit.zdb_id:
1460391-3
SSG:
12