In:
FEBS Letters, Wiley, Vol. 368, No. 2 ( 1995-07-17), p. 331-335
Abstract:
We report the isolation and characterization of a novel peptide with significant sequence homology to β‐defensins from human blood filtrate. The human β‐defensin‐1 (hBD‐1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD‐1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD‐1 shares the nine conserved amino acids characteristic for β‐defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD‐1 is present in nanomolar concentration in human plasma.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(95)00687-5
Language:
English
Publisher:
Wiley
Publication Date:
1995
detail.hit.zdb_id:
1460391-3
SSG:
12