In:
FEBS Letters, Wiley, Vol. 216, No. 2 ( 1987-06), p. 291-294
Abstract:
The dephosphorylation of the modulator subunit is an essential step in the kinase F A ‐mediated activation of the ATP,Mg‐dependent protein phosphatase. Mg 2+ is implicated in this autocatalytic dephosphorylation which is not effected by the addition of phosphoinhibitor‐1. Dephosphorylation of free modulator by the catalytic subunit is also largely Mg 2+ ‐dependent but can be abolished by phosphoinhibitor‐1 in concentrations comparable to the amount of modulator used as substrate (micromolar). The phosphorylase phosphatase activity of the catalytic subunit is inhibited by nanomolar concentrations of phosphoinhibitor‐1 and is completely independent of divalent cations.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(87)80708-1
Language:
English
Publisher:
Wiley
Publication Date:
1987
detail.hit.zdb_id:
1460391-3
SSG:
12