In:
Lipids, Wiley, Vol. 45, No. 5 ( 2010-05), p. 401-407
Abstract:
This study was conducted to determine whether saponified evening primrose oil (sap‐EPO) has the potential for use as a whitening agent and to investigate its underlying mechanisms of action. In B16 melanoma cells, sap‐EPO dose‐dependently inhibited isobutylmethylxanthine‐induced melanogenesis with no cytotoxicity. This decrease in melanin production was correlated with reduced enzyme activity and decreased mRNA and protein levels of tyrosinase. The mRNA levels of tyrosinase‐related proteins 1 and 2 decreased in response to treatment with sap‐EPO, indicating that it regulated tyrosinase at the transcriptional level. Expression of microphthalmia‐associated transcription factor was also decreased by sap‐EPO as evidenced by decreased mRNA and protein levels. Additionally, topical application of sap‐EPO resulted in efficient whitening of UVB‐induced hyperpigmentation of human skin. Taken together, these results suggest that sap‐EPO has the potential for use as a cosmetic whitening agent.
Type of Medium:
Online Resource
ISSN:
0024-4201
,
1558-9307
DOI:
10.1007/s11745-010-3405-4
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
2030265-4
SSG:
12