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    Online Resource
    Lactylation: a Passing Fad or the Future of Posttranslational Modification
    Springer Science and Business Media LLC ; 2022
    In:  Inflammation Vol. 45, No. 4 ( 2022-08), p. 1419-1429
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    In: Inflammation, Springer Science and Business Media LLC, Vol. 45, No. 4 ( 2022-08), p. 1419-1429
    Abstract: Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies.
    Type of Medium: Online Resource
    ISSN: 0360-3997 , 1573-2576
    URL: Article
    DOI: 10.1007/s10753-022-01637-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2015610-8
    detail.hit.zdb_id: 434408-X
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