In:
Oncology and Translational Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 2, No. 4 ( 2016-08), p. 179-184
Abstract:
The aim of the study was to compare flattening filter-free (FFF) beams and conventional flattening filter (FF) beams in volumetric modulated arc therapy (VMAT) for cervical cancer after surgery, through a retrospective planning study. Methods VMAT plans of FFF beams and normal FF beams were designed for a cohort of 15 patients. The prescribed dose was 45 Gy to 1.8 Gy per fraction, and at least 95% of the planning target volume received this dose. Doses were computed with a commercially available treatment planning system using a Monte Carlo (MC) algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices (HI and CI), as well as organs at risk (OAR) dose and volume parameters. Results FFF-VMAT was similar to FF-VMAT in terms of CI, but inferior to FF-VMAT considering HI. No statistically differences were observed between FFF-VMAT and FF-VMAT in following organ at risks including pelvic bone marrow, small bowel, bladder, rectum, and normal tissue (NT). . Conclusion For patients with cervical cancer after hysterectomy, the FFF beam achieved target and OAR dose distribution similar to that of the FF beam. Reduction of beam-on time in cervical cancer is beneficial.
Type of Medium:
Online Resource
ISSN:
2095-9621
DOI:
10.1007/s10330-016-0154-8
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2016
