In:
Rapid Communications in Mass Spectrometry, Wiley, Vol. 22, No. 19 ( 2008-10-15), p. 2993-2998
Kurzfassung:
Extractive electrospray ionization mass spectrometry (EESI‐MS) for real‐time monitoring of organic chemical reactions was demonstrated for a well‐established pharmaceutical process reaction and a widely used acetylation reaction in the presence of a nucleophilic catalyst, 4‐dimethylaminopyridine (4‐DMAP). EESI‐MS provides real‐time information that allows us to determine the optimum time for terminating the reaction based on the relative intensities of the precursors and products. In addition, tandem mass spectrometric (MS/MS) analysis via EESI‐MS permits on‐line validation of proposed reaction intermediates. The simplicity and rapid response of EESI‐MS make it a valuable technique for on‐line characterization and full control of chemical and pharmaceutical reactions, resulting in maximized product yield and minimized environmental costs. Copyright © 2008 John Wiley & Sons, Ltd.
Materialart:
Online-Ressource
ISSN:
0951-4198
,
1097-0231
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2008
ZDB Id:
2002158-6
ZDB Id:
58731-X
SSG:
11