In:
Phytotherapy Research, Wiley, Vol. 21, No. 5 ( 2007-05), p. 462-465
Abstract:
This study investigated whether carbenoxolone, oleanolic acid and ursolic acid affect ATP‐induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3 H‐glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3 H‐mucin secretion. The possible cytotoxicity of each agent was investigated with a lactate dehydrogenase assay. The results were as follows: (1) carbenoxolone, oleanolic acid and ursolic acid significantly inhibited the secretion of airway mucin induced by ATP; (2) none of the compounds showed significant cytotoxicity at any concentration. This result suggests that carbenoxolone, oleanolic acid and ursolic acid can regulate ‘mucin secretion induced by ATP’ – a phenomenon simulating mucus overproduction from inflamed airway epithelial cells – by directly acting on airway mucin‐secreting cells. Copyright © 2007 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0951-418X
,
1099-1573
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
1493490-5
detail.hit.zdb_id:
639136-9
SSG:
15,3