In:
Molecular Genetics & Genomic Medicine, Wiley, Vol. 6, No. 4 ( 2018-07), p. 541-546
Abstract:
Several susceptibility loci have been identified associated with Chinese Han systemic lupus erythematosus ( SLE ). Methods We carried out imputation of classical HLA alleles, amino acids and Single Nucleotide Polymorphisms ( SNP s) across the MHC region in Chinese Han SLE genome‐wide association study ( GWAS ) of mainland and Hong Kong populations for the first time using newly constructed Han‐ MHC reference panel followed by stepwise conditional analysis. Results We mapped the most significant independent association to HLA ‐ DQ β1 at amino acid position (Phe87, p = 7.807 × 10 −17 ) and an independent association at HLA ‐ DQB 1*0301 ( P condiational = 1.43 × 10 −7 ). Conclusion Our study illustrates the value of population‐specific HLA reference panel for fine‐mapping causal variants in the MHC .
Type of Medium:
Online Resource
ISSN:
2324-9269
,
2324-9269
DOI:
10.1002/mgg3.2018.6.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2734884-2