In:
Movement Disorders, Wiley, Vol. 23, No. 10 ( 2008-07-30), p. 1461-1465
Abstract:
To clarify the genetic correlation between parkin and PINK1 , we screened for PINK1 mutations in 175 parkinsonism patients with parkin mutations. We detected two sibling pairs and one sporadic patient carrying both parkin and PINK1 mutations. The age at onset of Parkinsonism of patients with the digenic mutations was lower than that of patients with the same parkin mutation alone. In addition, two of three patients carrying both parkin and PINK1 mutations had schizophrenia. These findings indicate that PINK1 mutation might modify parkin mutation‐positive Parkinsonism, and PINK1 mutations might be associated withpsychiatric disorders. © 2008 Movement Disorder Society
Type of Medium:
Online Resource
ISSN:
0885-3185
,
1531-8257
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
607633-6
detail.hit.zdb_id:
2041249-6