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    In: Journal of Surgical Oncology, Wiley, Vol. 125, No. 4 ( 2022-03), p. 664-670
    Abstract: This study investigates tumor recurrence patterns and their effect on postrecurrence survival following curative‐intent treatment of colorectal liver metastases (CRLM) to identify those who stand to benefit the most from adjuvant liver‐directed therapy. Methods This is a retrospective analysis of all patients that underwent liver resection and/or ablation for CRLM between 2007 and 2019. Postrecurrence survival was compared between recurrence locations. Risk factors for liver recurrence were sought. Results The study included 227 patients. Majority were treated with resection (71.0%) while combination resection/ablation (18.9%) and ablation alone (11.0%), were less common. At a median follow‐up of 3.0 years, recurrence was observed in 151 (66.5%) patients. Of those, liver, lung, and peritoneal recurrence were most common at 66.9%, 49.6%, and 9.2%, respectively. Median postrecurrence survival after liver, lung, and multisite recurrence was 39.6‐, 68.4‐, and 33.6 months, respectively. High tumor grade ( p   〈  0.014), perineural invasion ( p  = 0.002), and N0 node status ( p  = 0.017) of primary tumor correlated with liver recurrence on multivariate analysis. Conclusions Tumor grade, perineural invasion, and N0 node status of the primary tumor are associated with increased risk of liver recurrence after CRLM resection and represent a target population that may benefit the most from adjuvant liver‐directed regional chemotherapy.
    Type of Medium: Online Resource
    ISSN: 0022-4790 , 1096-9098
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 82063-5
    detail.hit.zdb_id: 1475314-5
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