In:
Journal of Surgical Oncology, Wiley, Vol. 122, No. 6 ( 2020-11), p. 1037-1042
Abstract:
Allogeneic blood transfusions are associated with worse postoperative outcomes in oncologic surgery. The aim of this study was to introduce a preoperative intervention to reduce transfusion rates in this population. Methods Adult patients undergoing major oncologic surgery in five categories with similar transfusion rates were recruited. Enrollees received a single preoperative intravenous dose of placebo or tranexamic acid (1000 mg). The primary outcome measure was perioperative transfusion rate. Secondary outcome measures included: estimated blood loss, thromboembolic events, morbidity, hospital length of stay, and readmission rate. Results Seventy‐six patients were enrolled, 39 in the tranexamic acid group and 37 in the placebo group, respectively. Demographics and surgery type were equivalent between groups. The transfusion rates were 8 out of 39 (20.5%) in the tranexamic acid group and 5 out of 37 (13.5%) in the placebo group, respectively ( P = .418). Median estimated blood loss was 400 mL (interquartile range [IQR] = 150‐600) in the tranexamic acid group compared with 300 mL (IQR = 150‐800) in the placebo group ( P = .983). There was one pulmonary embolism in each arm and no deep venous thrombosis ( P 〉 .999). Conclusion Preoperative administration of tranexamic acid at a 1000 mg intravenous dose does not decrease transfusion rates or estimated blood loss in patients undergoing major oncologic surgery.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
82063-5
detail.hit.zdb_id:
1475314-5
