In:
Journal of Neuroscience Research, Wiley, Vol. 95, No. 10 ( 2017-10), p. 1993-2004
Abstract:
Macroautophagy is an evolutionally conserved membrane trafficking pathway that delivers intracellular materials to lysosomes for degradation and recycling. Rab7, as a member of the Rab GTPase superfamily, has a unique role in the regulation of macroautophagy, especially in modulating autophagy flux. The functional states of Rab7 generally switch between GTP‐bound and GDP‐bound states under the control of guanine nucleotide exchange factors (GEFs) and GTPase‐activating proteins (GAPs). Activated GTP‐Rab7 is capable of regulating autophagosome formation, autophagosome transportation along microtubules, endosome and autophagosome maturation, as well as lysosome biogenesis via interacting with its effector molecules. Rab7‐mediated macroautophagy is closely associated with various pathological processes of several neurologic diseases, such as Parkinson's disease, Huntington's disease, Alzheimer's disease, Charcot‐Marie‐Tooth type 2B disease, and cerebral ischemic diseases. Considering that macroautophagy can be the prime therapeutic target in certain nervous system diseases, in‐depth study of Rab7 in the regulation of macroautophagy may be helpful to identify novel strategies for the treatment of autophagy‐related neurologic diseases. © 2017 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
0360-4012
,
1097-4547
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1474904-X
detail.hit.zdb_id:
195324-2
SSG:
12
